Using an orthogonal antibody testing approach, we estimated that about 0.6% of nontriaged adults from the greater Vancouver, Canada, area between May 17 and June 19, 2020, showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Preexisting cross-reactivity to SARS-CoV-2 occurs in the absence of prior viral exposure.
Lavoie PM BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. McDermott AB Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Douek DC Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada. Pelech S BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Goldfarb DM Vaccine Evaluation Centre, BC Children's Hospital Research Institute, Vancouver, British Columbia. Jassem AN Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. Sekirov I BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Esposito D Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. Mehalko J Kinexus Bioinformatics Corporation, Vancouver, British Columbia, Canada. Irvine M Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada. Barakauskas VE BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. Görges M Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada. Liu AC Department of Anesthesiology, Surrey Memorial Hospital (SMH), Surrey, British Columbia, Canada. Basappa M Department of Anesthesiology & Pain Medicine, University of Alberta, Edmonton, Alberta, Canada. Winkler DF Department of Anesthesiology, Surrey Memorial Hospital (SMH), Surrey, British Columbia, Canada. Cheung C Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA. 
Mehta D Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.Gelinas J BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.Narpala S Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, Maryland, USA.
Dada S Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.O'Connell SE BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.Michalski C Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.Majdoubi A BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.
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